PADCEV (enfortumab vedotin-ejfv) for injection
PADCEV is a Nectin-4-directed antibody and microtubule inhibitor conjugate indicated for the treatment of adult patients with locally advanced or metastatic urothelial cancer who have previously received a programmed death receptor-1 (PD-1) or programmed death-ligand 1 (PD-L1) inhibitor, and a platinum-containing chemotherapy in the neoadjuvant/adjuvant, locally advanced or metastatic setting. Brand Name: PADCEV (enfortumab vedotin-ejfv) for injection, for intravenous use Initial U.S. Approval: 2019
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PADCEV (enfortumab vedotin-ejfv) for injection
Enfortumab vedotin-ejfv is a type of targeted therapy called an antibody-drug conjugate. It is made of a monoclonal antibody chemically linked to a cancer-killing drug. The monoclonal antibody binds to a protein on the surface of some cancer cells. The linked drug enters these cancer cells and kills them. Enfortumab vedotin-ejfv may also stimulate the immune system to kill cancer cells.
Padcev is a cancer medicine for treating adults with urothelial cancer (a cancer of the bladder and urinary tract). Padcev is for patients whose cancer is advanced or has spread and who have already had platinum- based chemotherapy and an immunotherapy. It contains the active substance enfortumab vedotin.
A drug used alone or with pembrolizumab to treat adults with certain types of urothelial cancer (a type of cancer in the bladder or urinary tract) that have spread or cannot be removed by surgery. It is also being studied in the treatment of other types of cancer. Padcev contains a monoclonal antibody that binds to a protein called nectin-4, which is found on some cancer cells. It also contains an anticancer drug, which may help kill cancer cells. Padcev may also help the immune system kill cancer cells. It is a type of antibody-drug conjugate. Also called enfortumab vedotin.
Enfortumab vedotin is indicated for the treatment of adults with locally advanced (when cancer has grown too large to be surgically removed) or metastatic (when cancer cells spread to other parts of the body) urothelial cancer who have previously received a programmed death receptor-1 (PD-1) or programmed death ligand 1 (PD-L1) inhibitor and a platinum-containing chemotherapy.
Drug (Brand / Generic): PADCEV / enfortumab vedotin-ejfv
Current Indications: urothelial cancer (a type of cancer in the bladder or urinary tract)
Marketed by:: Astellas Pharma US, Inc
Approval Date: 2019
Dosage forms and strengths of PADCEV (enfortumab vedotin-ejfv).
For Injection: 20 mg and 30 mg of enfortumab vedotin-ejfv as a lyophilized powder in a single-dose vial for reconstitution.
Find Reference Updates
What is Padcev and how does it work?
Astellas, cited on Nov 20, 2020
FDA approves new type of therapy to treat advanced urothelial cancer
FDA press release, December 18, 2019
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